4.4 Article

Pd/C-catalyzed heterocyclization during copper-free Sonogashira coupling: synthesis of 2-benzylimidazo[1,2-a]pyrimidines in water

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 2, Pages 228-230

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.10.168

Keywords

Pd/C-catalyzed; Sonogashira reaction; Aryl iodide; Imidazopyrimidine

Funding

  1. Research Council of Shahrood University of Technology

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An efficient synthesis of 2-benzylimidazo[1,2-a]pyrimidines in water is accomplished via Pd/C-catalyzed reaction of 2-imino-1-(2-propynyl)pyrimidine with various aryl iodides in the presence of K2CO3 as the base. (C) 2010 Elsevier Ltd. All rights reserved.

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