Journal
TETRAHEDRON LETTERS
Volume 52, Issue 49, Pages 6581-6583Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.09.133
Keywords
Poly(ethylene-glycol); Magnetic resonance imaging; Polymer; F-19-NMR; Fluorine
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Funding
- Cariplo Foundation (Milano)
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Readily available, low cost, hydrosoluble poly(ethylene-glycol) derivatives of 2-(trifluoromethyl)-3,3,3-trifluoro-propanoic acid were easily synthesized and their properties as MRI agents are preliminarily investigated. Two novel polymers, of 2356 Da and 756 Da, respectively, both showing a single F-19 signal at NMR in deuterated chloroform and D2O were fully characterized; both compounds were shown to be soluble in water. However when experiments of in vitro MR imaging were conducted a clear imaging was obtained only with the sample of 756 MW, pointing at the importance of the fluorine content of the carrier. (C) 2011 Published by Elsevier Ltd.
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