Journal
TETRAHEDRON LETTERS
Volume 52, Issue 51, Pages 6923-6926Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.10.065
Keywords
Aspergillus sp.; Biosynthesis; Prenylated indole alkaloids
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [23108518]
- Nagase Science and Technology Foundation
- National Institutes of Health [CA70375]
Ask authors/readers for more resources
Two reverse-prenylated indole alkaloids, deoxybrevianamide E and 6-hydroxydeoxybrevianamide E, are proposed as biosynthetic precursors for advanced metabolites isolated from the marine-derived Aspergillus sp. In order to uncover the role of the alkaloids in the biosynthetic pathway, the feeding experiments of the [C-13](2)-[N-15]-labeled deoxybrevianamide E and 6-hydroxydeoxybrevianamide E were performed to afford the metabolites, which were produced by oxidation and successive pinacol-type rearrangement of the isoprenyl units. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available