Journal
TETRAHEDRON LETTERS
Volume 52, Issue 42, Pages 5508-5511Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.08.070
Keywords
Isoindoline; Domino reaction; Cycloisomerization; Sonogashira coupling; Microwave
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Funding
- Harvard NeuroDiscovery Center
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An efficient microwave assisted one-pot synthesis of substituted 3-(phenylmethylene)isoindolin-1-ones is reported via a copper-free Sonogashira coupling and a regioselective 5-exo-dig cycloisomerization. This domino reaction was also extended to other related heterocycles. (C) 2011 Elsevier Ltd. All rights reserved.
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