Journal
TETRAHEDRON LETTERS
Volume 52, Issue 33, Pages 4262-4265Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.04.100
Keywords
Esterification; Ritter reaction; TBME; Regioselective; Chemoselective
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Funding
- R. L. Fine Chem
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tert-Butyl methyl ether (TBME) has been effectively used as a reagent for esterification of carboxylic acids. By varying amounts of sulfuric acid, a remarkable regioselectivity in esterification has been demonstrated. Additionally, under the present reaction conditions, one-pot esterification and Ritter reaction are achieved in almost quantitative yield. (C) 2011 Elsevier Ltd. All rights reserved.
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