Journal
TETRAHEDRON LETTERS
Volume 52, Issue 4, Pages 530-533Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.11.106
Keywords
Iron catalysis; Quinolines; Cascade reaction; Michael addition/cyclization
Categories
Funding
- National Natural Science Foundation of China [20572025, 20872037]
- Laboratory of Organic Functional Molecules
- Sino-French Institute of ECNU
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An efficient iron-catalyzed cascade Michael addition-cyclization of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones, and o-aminobenzyl alcohols with ynones for the synthesis of 3-carbonyl quinolines is reported. The reactions proceed to afford 3-carbonyl quinoline derivatives with or without substituent at the C-4 position in good to high yields using Iron(III) chloride hexahydrate as the catalyst in the air. (C) 2010 Elsevier Ltd. All rights reserved.
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