Regioselective synthesis of pyridoquinolones and pyridocoumarins via molecular iodine-mediated 6-endo-dig electrophilic cylization

Angular-pyridoquinolone and pyridocoumarin derivatives have been efficiently synthesized in 60-95% yields by molecular iodine-mediated cyclization of easily available starting materials, 6-(N-propargyl)amino quinolone and coumarin derivatives, in the presence of NaHCO(3). The reaction was carried out at room temperature. (C) 2010 Elsevier Ltd. All rights reserved.