Journal
TETRAHEDRON LETTERS
Volume 51, Issue 7, Pages 1064-1068Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.12.079
Keywords
Spiropyrrolidine oxindoles; Spiroindane-1; 3-Diones; Multi-component reaction; Isatylidene malononitrile; Dipolarophile
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Funding
- Council of Scientific and Industrial Research, New Delhi, India
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A series of dispiropyrrolidine bisoxindoles were synthesized via a multicomponent 1,3-dipolar cyclo-addition reaction of isatin, sarcosine and isatylidene malononitrile in refluxing methanol. Also a series of spiropyrrolidine oxindoles and spiroindane-1,3-diones were synthesized using 2-(1H-Indole-3-carbonyl)-3-phenyl-acrylonitrile and 2-(1,3-dioxo-indan-2-ylidene)-malononitrile as dipolarophiles, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
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