Journal
TETRAHEDRON LETTERS
Volume 51, Issue 12, Pages 1582-1584Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.01.056
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Funding
- CSIR-UGC New Delhi
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We have developed an efficient non-ionic surfactant (Triton X-100) catalyzed multicomponent synthesis of Betti base from secondary amine, aromatic aldehydes, and beta-naphthol using Mannich-type reaction in water. Lewis and Bronsted acid catalysts, ionic and non-ionic surfactant have been screened for the reaction. Non-ionic surfactant (Triton X-100) gave the best results and the reaction proceeds through the imine formation, which is stabilized by colloidal dispersion and undergoes nucleophilic addition to afford the corresponding N,N-dialkylated Betti base in excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.
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