4.4 Article

Efficient synthesis of deuterated 1,2,3-triazoles

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 48, Pages 6275-6277

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.09.097

Keywords

Acetylene; Copper; Click-reaction; Deuterium; Triazoles

Funding

  1. Magyary Zoltan Felsooktatasi Kozalapitvany, EEA and Norway Grants
  2. OTKA-NKTH [CK 80763]
  3. The European Union [TAMOP 4.2.1./B-09/KMR-2010-0003]
  4. European Social Fund [TAMOP 4.2.1./B-09/KMR-2010-0003]

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A wide variety of 1-monosubstituted 1,2,3-triazoles were synthesized efficiently via a copper-catalyzed click-reaction between azides and acetylene gas, generated in situ from CaC2 with the addition of H2O or D2O. (C) 2010 Elsevier Ltd. All rights reserved.

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