Journal
TETRAHEDRON LETTERS
Volume 51, Issue 26, Pages 3443-3445Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.04.128
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Funding
- National Basic Research Program of China (973 Program) [2009CB522300]
- National Natural Science Foundation of China [30830113]
- MOST [2009ZX09501-029, 2009ZX09501-013]
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The isolation, structure elucidation, and relative stereochemistry assignment of a novel illudane-illudane bis-sesquiterpene, agrocybone (1), from the basidiomycete Agrocybe salicacola, were reported. Agrocybone represents a structure with eight rings (including two Spiro rings) and seven stereogenic carbon atoms. Agrocybone was found to exhibit weak antiviral activity against respiratory syncytial virus (RSV) with IC(50) value of 100 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
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