Journal
TETRAHEDRON LETTERS
Volume 51, Issue 45, Pages 5947-5949Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.09.027
Keywords
Trifluoromethylation; Indole; Catalysis; Regioselective
Categories
Funding
- RIKEN
- [19028065]
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Direct C2-selective trifluoromethylation of indole derivatives was achieved with Togni's hypervalent iodine reagent and CuOAc as a catalyst in MeOH under mild conditions, affording the desired C2-trifluoromethylated indoles in good yield (up to 90%). (C) 2010 Elsevier Ltd. All rights reserved.
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