4.4 Article

The first intramolecular Heck-Matsuda reaction and its application in the syntheses of benzofurans and indoles

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 16, Pages 2102-2105

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.02.011

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Funding

  1. Foundation of the State of Sao Paulo (FAPESP)
  2. Brazilian National Research Council (CNPq)

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In this Letter, we report, for the first time, the development of an efficient method for the intramolecular Heck reaction of arenediazonium salts in the synthesis of benzofuran and indole derivatives. In addition, this methodology allowed the synthesis of a series of dihydrobenzofuran acetic acid derivatives via a domino Heck-Matsuda coupling-carbonylation reaction. (c) 2010 Elsevier Ltd. All rights reserved.

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