Magnetically separable Fe3O4 nanoparticles: an efficient catalyst for the synthesis of propargylamines

Magnetically separable Fe3O4 nanoparticles endow with all efficient and economic route for the synthesis of propargylamines by the three-component Coupling of aldehyde, amine, and alkyne through C-H activation. The reaction is especially effective for reactions involving aliphatic aldehydes and no additional co-catalyst or activator is required. High catalytic activity and ease of recovery using all external magnetic field are additional eco-friendly attributes of this catalytic system. The catalyst was recycled for five times without a significant loss of catalytic activity. (C) 2010 Elsevier Ltd. All rights reserved.