4.4 Article

Iridium-catalyzed formylation of amines with paraformaldehyde

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 44, Pages 5804-5806

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.08.106

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Funding

  1. EPSRC
  2. GlaxoSmithkline
  3. EPSRC [EP/G028141/1, EP/F037643/1, EP/F038321/1] Funding Source: UKRI
  4. Engineering and Physical Sciences Research Council [EP/F038321/1, EP/G028141/1, EP/F037643/1] Funding Source: researchfish

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Amines have been formylated using aqueous formaldehyde or paraformaldehyde and the iridium catalyst [Cp*IrI2](2). Paraformaldehyde acts as both a formylating agent and an oxidant. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

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