4.4 Article

Synthesis of phenothiazine-corrole dyads: the enhanced DNA photocleavage properties

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 26, Pages 3439-3442

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.04.112

Keywords

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Funding

  1. National Natural Science Foundation of China [20771039, 20625205, 20971046]
  2. Natural Science Foundation of Guangdong Province [9351027501000003]

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Three new phenothiazine-corrole dyads were prepared by the reaction of phenothiazine-10-carbonyl chloride and mono-hydroxyl triaryl corrole in the presence of DBU. As compared to corrole monomer, these phenothiazine-corrole dyads exhibit significant enhanced DNA photocleavage activity as compared to corrole monomer precursors. (C) 2010 Elsevier Ltd. All rights reserved.

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