Journal
TETRAHEDRON LETTERS
Volume 51, Issue 39, Pages 5109-5111Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.07.021
Keywords
4-Center 3-component Ugi; Ketoacids; Microwave; Solvent-free; Lactams
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Funding
- Conseil Regional Nord-Pas de Calais, DRRT PRIM [2008-07 PRIM-SP]
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Five- and six-membered lactams were synthesized via a 4-center 3-component Ugi reaction by combining amines, isocyanides, and ketoacids under solvent-free microwave conditions. The reaction was carried out in much shorter times and the yields were improved in comparison to classical conditions. (c) 2010 Elsevier Ltd. All rights reserved.
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