4.4 Article

Iodine-catalyzed one-pot synthesis of amides from nitriles via Ritter reaction

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 21, Pages 2813-2819

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.03.057

Keywords

Ritter reaction; Iodine-catalyzed; Nitriles; Alcohols; Amides

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Ritter reactions of alcohols and tert-butyl acetate with various nitriles were performed using iodine as a mild and effective catalyst under heating conditions to afford the corresponding amides in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.

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