4.4 Article

Direct C-3 arylation of N-acetylindoles with anisoles using phenyliodine bis(trifluoroacetate) (PIFA)

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 15, Pages 2004-2006

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.02.022

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Funding

  1. National Natural Science Foundation of China [20602033]
  2. National Basic Research Program of China [2006CB922001]

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The direct C-3 arylation of N-acetylindoles with anisoles was described in this Letter. In the presence of phenyliodine bis(trifluoroacetate) (FIFA) and BF(3)-Et(2)O, the reaction of N-acetylindoles with anisoles provided C-3 arylindoles with high regioselectivity under mild conditions. (C) 2010 Elsevier Ltd. All rights reserved.

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