Journal
TETRAHEDRON LETTERS
Volume 51, Issue 19, Pages 2660-2663Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.03.037
Keywords
Heterocycles; Silver; 1,2,4-Triazole; Scale-up; Enantiopure
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We report a new method using silver benzoate instead of mercury salts as a key reagent for the synthesis of 3,4,5-trisubstituted 1,2,4-triazoles. This method allows the introduction of a large variety of substituents in the three positions. We demonstrated that we could introduce one chiral center without any loss of the optical purity. This method is compatible with at least multi-gram scale-up. (C) 2010 Elsevier Ltd. All rights reserved.
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