Journal
TETRAHEDRON LETTERS
Volume 51, Issue 18, Pages 2477-2479Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.02.161
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Bioassay-guided fractionation of the crude CH(2)Cl(2)/MeOH extract from the Australian ascidian Polysyncraton echinatum led to the isolation of a new pyridoacridine alkaloid, 12-deoxyascididemin (1), along with two known analogues, ascididemin (2) and eilatin (3). The structure of 1 was determined following extensive analysis of 1D/2D NMR and MS data. Biological evaluation showed that compounds 1-3 are potent antitrypanosomal agents with IC(50) values of 0.077, 0.032, and 1.33 mu M against Tryponosoma brucei brucei, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
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