Journal
TETRAHEDRON LETTERS
Volume 51, Issue 8, Pages 1152-1154Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.12.049
Keywords
Hydrogen peroxide; Reactive oxygen species (ROS); Coumarin; Click chemistry; Fluorescence
Categories
Funding
- NIH [CA123329, CA113917, GM086925, GM084933]
- Georgia Cancer Coalition
- Georgia Research Alliance
- Molecular Basis of Diseases program at GSU
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Herein a water-soluble 'click' modified coumarin-based fluorescent probe for hydrogen peroxide is reported. This probe shows significant intensity increases (up to fivefold) in near-green fluorescence upon reaction with hydrogen peroxide, and good selectivity over other reactive oxygen species. (C) 2009 Elsevier Ltd. All rights reserved.
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