Journal
TETRAHEDRON LETTERS
Volume 51, Issue 44, Pages 5840-5842Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.09.005
Keywords
Tetrahydropyran; Amino acid; oxa-Michael reaction; Aldol reaction; Reductive etherification; Exiguolide
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Funding
- CSIR-New Delhi
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A chiral-pool approach for the construction of methylene bis-tetrahydropyran subunit, C-1-C-16 fragment, of (-)-exiguolide is described. The synthesis was efficiently accomplished starting from L-glutamic acid and L-aspartic acid involving oxa-Michael reaction and an aldol-driven-reductive etherification as key steps for the formation of tetrahydropyran ring. (C) 2010 Elsevier Ltd. All rights reserved.
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