Journal
TETRAHEDRON LETTERS
Volume 51, Issue 46, Pages 6034-6036Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.09.037
Keywords
Radiofluorination; 1,3-Thiazole; Microwave-assisted synthesis
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Funding
- National Institutes of Health (NIMH)
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2-Fluoro-1,3-thiazoles were rapidly and efficiently labeled with no-carrier-added fluorine-18 (t(1/2) = 109.7 min) by treatment of readily prepared 2-halo precursors with cyclotron-produced [F-18]fluoride ion. The [F-18]2-fluoro-1,3-thiazolyl moiety constitutes a new and easily-labeled structural motif for prospective molecular imaging radiotracers. Published by Elsevier Ltd.
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