Journal
TETRAHEDRON LETTERS
Volume 51, Issue 39, Pages 5207-5209Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.07.144
Keywords
Salvinorin A; Neoclerodane diterpenoid; Smoke; Opioid receptor
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Funding
- NIDA, NIH [R01-DA019688]
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Salvinorin A is a naturally occurring potent and selective kappa opioid receptor agonist, and smoking salvinorin A produces the most intense hallucinogenic effects in human. Eight neoclerodane diterpene derivatives were isolated from the smoke of salvinorin A, and their structures were identified by spectroscopic methods. The major structural changes include epimerizations, eliminations, and rearrangements. (C) 2010 Elsevier Ltd. All rights reserved.
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