4.4 Article

Solvent-free Horner-Wadsworth-Emmons reaction using DBU

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 25, Pages 3297-3299

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.04.072

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan

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The solvent-free Horner-Wadsworth-Emmons reaction with a variety of aldehydes using 1.5 equiv of DBU gave E-alpha,beta-unsaturated esters and ketones in high yields. The E-selectivity was high and the used DBU was recovered. (C) 2010 Elsevier Ltd. All rights reserved.

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