4.4 Article

Synthesis of 4-allylquinazolines from N-(2-cyanoaryl)amides via the In-mediated allylation of nitrile and dehydrative cyclization cascade

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 20, Pages 2774-2777

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.03.076

Keywords

Quinazolines; Indium; Nitrile; Allylation; Barbier reaction

Funding

  1. Ministry of Education, Science and Technology [2009-0070633]
  2. National Research Foundation of Korea [과06B1512] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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The reaction of allylindium reagents and N-(2-cyanoaryl)amides afforded 2-substituted-4-allylquinazolines in good yields via the indium-mediated Barbier-type allylation of nitrile and the following dehydrative cyclization cascade. (C) 2010 Elsevier Ltd. All rights reserved.

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