Journal
TETRAHEDRON LETTERS
Volume 51, Issue 7, Pages 1099-1102Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.12.089
Keywords
3-Aminocoumarin; Heteroarylhalides; Palladium acetate; C-N bond coupling reaction; BINAP; Cesium carbonate
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Funding
- Calcutta University
- University Grants Commission, New Delhi
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New 3-(heteroaryl)aminocoumarin derivatives were synthesized from 3-aminocoumarin, applying optimized Buchwald-Hartwig amination conditions using Palladium acetate, Cesium carbonate, and BINAP in 1,4-dioxane employing elevated temperature conditions and under an argon atmosphere. The target heteroarylaminocoumarin derivatives were obtained in moderate to good yields ranging from 56% to 98%. The procedure described Could be widely employed for the preparation of new heterocyclic compounds when one of the core moieties is coumarin and has the potential to be active drug candidates. (C) 2009 Elsevier Ltd. All rights reserved.
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