4.4 Article

Mild and efficient ligand-free copper-catalyzed condensation for the synthesis of quinazolines

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 4, Pages 758-760

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.11.133

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Condensation of o-iodobenzaldehydes la-c with amidine hydrochlorides 2a-p under ligand-free copper-catalyzed Ullmann N-arylation conditions afforded the corresponding quinazolines 3a-r in good to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

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