Journal
TETRAHEDRON LETTERS
Volume 51, Issue 2, Pages 313-316Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.11.011
Keywords
Phosgene; Carbon-11; Radiolabelling
Categories
Funding
- EC-FP6 [LSHB-Ct-2005-512146]
- EMIL [LSH-2004-503569]
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A new flow-through system for the production of [C-11]phosgene, a versatile labelling agent in radiochemistry for PET, is described. Cyclotron-produced [C-11]CH4 is mixed with Cl-2 and converted into [C-11]CCl4 by passing the mixture through an empty quartz tube at 510 degrees C. The Outflow is directed through a Sb-filled guard that takes Out Cl-2 and then, without intentional O-2 addition, through a second empty quartz tube at 750 degrees C, giving rise to [C-11]phosgene in 30-35% radiochemical yield. (C) 2009 Elsevier Ltd. All rights reserved.
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