Journal
TETRAHEDRON LETTERS
Volume 51, Issue 11, Pages 1493-1496Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.01.036
Keywords
Alkynes; Gold catalyst; Hydroamination; Hydroalkoxylation; Hydroarylation
Categories
Funding
- Council of Scientific and Industrial Research, India
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A process involving gold(I)-catalyzed formal carboamination of alkynes for the synthesis of C-3-substituted indoles has been developed. The procedure utilizes easily accessible starting materials such as 2-alkynylanilines and alkynols. A series of C-3-functionalized indoles are accessible by using this one-pot strategy. Mechanistically, the reaction involves three catalytic cycles and each of them is essentially catalyzed by a single metal catalyst, that is, Ph3PAuOTf. (C) 2010 Published by Elsevier Ltd.
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