Journal
TETRAHEDRON LETTERS
Volume 51, Issue 9, Pages 1322-1325Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.12.139
Keywords
Chromene; Tandem reaction; Enantioselective; Cinchona alkaloid; Organocatalysis; 1,2-Cyclohexanedione; Benzylidenemalononitrile
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Funding
- Welch Foundation [AX-1593]
- National Institute of General Medical Sciences [1SC1GM082718-01]
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2-Amino-8-oxo-tetrahydro-4H-chromene-3-carbonitriles were synthesized for the first time from a tandem Michael addition-cyclization reaction between cyclohexane-1,2-dione and benzylidenemalononitriles An enantioselective synthesis of these compounds was achieved in moderate ee values (up to 63% ee) by using a cinchona alkaloid-derived thiourea catalyst. (C) 2010 Elsevier Ltd All rights reserved.
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