4.4 Article

Synthesis of tetralin and chromane derivatives via In-catalyzed intramolecular hydroarylation

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 33, Pages 4466-4469

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.06.091

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Funding

  1. National Science Foundation of China [20702012]
  2. NCET in university [NCET-09-0334]
  3. Chinese Ministry of Education

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IN(OTf)(3) was found to be an effective catalyst for the cyclization of omega-aryl-1-alkenes to form tetralin and chromane derivatives Compared with the known Ru-catalyzed version, the In-catalyzed intramolecular cyclization was found to give higher yields and cleaner reactions in some cases The use of cheaper indium salts instead of the expensive noble metal Ru can be advantageous when the reaction is run on a large scale (C) 2010 Elsevier Ltd All rights reserved

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