Journal
TETRAHEDRON LETTERS
Volume 51, Issue 31, Pages 4027-4029Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.05.089
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
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Efficient synthesis of the tricyclic key intermediate 2 for (-)-FR901483 1 was accomplished. The precursor of the intramolecular aldol reaction 4b is constructed by the Ugi 4CC reaction and subsequent intramolecular Dieckmann condensation. This approach allows a fully stereocontrolled total synthesis of (-)-FR901483, which would provide various derivatives. (C) 2010 Elsevier Ltd. All rights reserved.
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