4.4 Article

Highly effective and enantioselective α-amination of aldehydes promoted by chiral proline amide-thiourea bifunctional catalysts

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 37, Pages 4870-4873

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.07.042

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Funding

  1. National Natural Science Foundation of China [20802075]
  2. Chinese Academy of Sciences

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A series of secondary amine-thiourea catalysts derived from L-proline and chiral diamine were prepared and successfully applied to the highly effective and enantioselective alpha-amination of unmodified aldehydes with various azodicarboxylates in excellent yields (up to 99%) and enantioselectivities (up to 99% ee) within a few minutes. (C) 2010 Elsevier Ltd. All rights reserved.

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