4.4 Article

K2CO3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 37, Pages 4866-4869

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.07.041

Keywords

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Funding

  1. National Basic Research Program of China (973 Program) [2010CB126101]
  2. Shanghai Foundation of Science of Technology [09391911800]
  3. Shanghai Leading Academic Discipline Project [B507]

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A novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates by three-component reaction of ethyl trifluoroacetoacetate, aldehydes, and ammonium acetate in the presence of K2CO3 under solvent-free conditions via sequential Hantzsch reaction/dehydration/dehydrofluorination in a one-pot process was described. (C) 2010 Elsevier Ltd. All rights reserved.

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