4.4 Article

Oxidation of 4-carboxylate thiazolines to 4-carboxylate thiazoles by molecular oxygen

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 13, Pages 1751-1753

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.01.091

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Funding

  1. National Natural Science Foundation [20902111]
  2. Ministry of Education of China and the State Key Laboratory of Drug Research

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A facile and environment-benign oxidation by molecular oxygen was applied for the conversion of 4-carboxylate thiazolines to 4-carboxylate thiazoles. The substituent effect on thiazoline ring was investigated. it was found that electron-poor group on the thiazoline ring could facilitate the oxidation. (C) 2010 Elsevier Ltd. All rights reserved.

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