4.4 Article

Direct oxidative cyclization of 3-arylpropionic acids using PIFA or Oxone: synthesis of 3,4-dihydrocoumarins

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 1, Pages 192-196

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.10.112

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Funding

  1. National Natural Science Foundation of China [20602033]
  2. National Basic Research Program of China [2006CB922001]

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The direct oxidative cyclization of 3-arylpropionic acids using PIFA or Oxone is reported. In the presence of BF(3)center dot OEt(2), the reaction of 3-arylpropionic acids with PIFA or Oxone proceeded smoothly at 30 degrees C to give 3,4-dihydrocoumarins in good to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

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