Journal
TETRAHEDRON LETTERS
Volume 51, Issue 29, Pages 3775-3778Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.05.044
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Funding
- Korean Government (MOEHRD) [2009-0071807]
- Ministry of Education, Science and Technology [2009-0093817]
- Korean Ministry of Education Science & Technology(MEST) [2008-00656]
- Ministry of Education, Science & Technology (MoST), Republic of Korea [2008-00656] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0071807] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Fluorescein mercury acetate (FMA) derivative can be used as a chemosensor for NADH that plays key roles in cellular energy metabolism and dehydrogenase enzymatic reactions. The sensor recognizes NADH by two mercury metal ions in the compound using the metal-anion interaction and its subsequent binding-induced fluorescence changes of FMA. The FMA can detect an aqueous NADH concentration of approximately 1.0 uM and has a high selectivity over various anions including NAD(+), the oxidized form of NADH. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
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