Journal
TETRAHEDRON LETTERS
Volume 51, Issue 17, Pages 2326-2328Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.02.121
Keywords
alpha,beta-Unsaturated trifluoromethyl ketones; Indoles; Enantioselective Friedel-Crafts alkylation
Categories
Funding
- Open Research Center
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The first catalytic enantioselective Friedel-Crafts alkylation of indoles with alpha,beta-unsaturated trifluoromethyl ketones has been accomplished. The reaction was achieved in the presence of the Dy(OTf)(3)/Pybox complex, producing the desired products in high yields (up to 99%) with good enantioselectivities (up to 86% ee). The absolute stereochemistry of the resulting adducts was determined by X-ray analysis. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
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