4.4 Article

Short and straightforward total synthesis of Ammosamide B

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 37, Pages 4806-4807

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.06.022

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Funding

  1. National Major Scientific and Technological Special Project [2009ZX09501-006]

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A simple and five steps total synthesis of Ammosamide B has been developed. The tricyclic pyrroloquinoline in Ammosamides was constructed in one step based on Doebner-Miller reaction between 1,3-diamine-4,6-dinitrobenzene 8 and dimethyl-2-oxo glutaconate 9. (C) 2010 Elsevier Ltd. All rights reserved.

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