Journal
TETRAHEDRON LETTERS
Volume 51, Issue 27, Pages 3536-3537Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.04.121
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Funding
- Korean Government [2009-0087801]
- National Research Foundation of Korea [2009-0087801] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A practical and efficient procedure for the synthesis of a potent calcimimetic (+)-NPS R-568 was developed. This procedure includes as the key step the asymmetric reductive acylation of a ketoxime intermediate catalyzed by a Pd nanocatalyst and a lipase in combination. The target compound was prepared from commercially available 3'-methoxyacetophenone via five steps in overall 63% yield. (C) 2010 Elsevier Ltd. All rights reserved.
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