Journal
TETRAHEDRON LETTERS
Volume 51, Issue 17, Pages 2222-2224Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.02.063
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Funding
- Nuffield Foundation
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2-Acetamido-1,2-dideoxy-D-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from D-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of alpha-N-acetyl-galactosaminidases (K-i 0.081 mu M from chicken liver, K-i 0.136 mu M from Charonia lampas). DGJNAc is a good competitive-whereas the enantiomer L-DGJNAc is a very weak but non-competitive inhibitor of beta-hexosaminidases. (C) 2010 Published by Elsevier Ltd.
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