4.4 Article

PhIO/Bu4NI mediated oxidative cyclization of amidoalkylation adducts for the synthesis of N-benzoyl aziridines and oxazolines

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 2, Pages 453-456

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.11.069

Keywords

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Funding

  1. National Natural Science Foundation of China [20702006]
  2. Shanghai Rising-Star program [07QA14007]
  3. Fudan University

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An efficient oxidative cyclization of amidoalkylation adducts of activated methylene compounds with the combination of iodosobenzene and a catalytic amount of tetrabutylammonium iodide under neutral conditions is reported. The reaction affords N-benzoyl aziridines or oxazolines in moderate to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

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