4.4 Article

Enantioselective addition of oxindoles to aliphatic α,β-unsaturated aldehydes

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 48, Pages 6624-6626

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.09.038

Keywords

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Funding

  1. Spanish Ministry of Science and Education [AYA2006-15648-C02-01]
  2. ICREA
  3. Ministerio de Ciencia a Innovacion

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A highly enantioselective organocatalytic oxindole addition to alpha,beta-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available chiral secondary amines, affording the corresponding adducts with good yields and with moderate diastereoselectivities. (C) 2009 Elsevier Ltd. All rights reserved.

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