Efficient synthesis of phosphorus-containing dendrimers capped with isosteric functions of amino-bismethylene phosphonic acids

An efficient synthetic strategy to synthesize phosphorus-containing dendrimers capped with isosteric acid functions derived from tyramine is described. The method is demonstrated on a first generation dendrimer that can be easily capped with 12 amino(bismethylene) sulfonic acids and amino(bismethylene) carboxylic acids that are strict analogs of the corresponding amino(bismethylene) phosphonic acids. (c) 2009 Elsevier Ltd. All rights reserved.