Journal
TETRAHEDRON LETTERS
Volume 50, Issue 28, Pages 4167-4169Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.04.126
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Funding
- JSPS KAKENHI [20590027]
- Grants-in-Aid for Scientific Research [20590027] Funding Source: KAKEN
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Direct, efficient syntheses of the benzimidazo[2,1-a]isoquinoline ring system have been achieved with 2-bromoarylaldehydes, terminal alkynes, and 1,2-phenylenediamines by a microwave-accelerated tandem process in which a Sonogashira coupling, 5-endo cyclization, oxidative aromatization, and 6-endo cyclization can be performed in a single synthetic operation. (C) 2009 Elsevier Ltd. All rights reserved.
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