Journal
TETRAHEDRON LETTERS
Volume 50, Issue 32, Pages 4658-4662Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.05.113
Keywords
Diterpenoid dimer; Erythrophleum succirubrum; TRAIL-resistance overcoming activity; Cassaine
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan
- Japan Science and Technology Agency Innovation Branch Chiba (JST)
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Activity-guided fractionation of Erythrophleum succirubrum for TRAIL resistance-overcoming activity led to the isolation of four new cassaine diterpenoid dinners, named erythrophlesins A-D (1-4). Their structures were elucidated by spectral data to show that they have an unsymmetrical dimeric structure through an ester bond between two cassaine diterpenoids. These new compounds were revealed to have a significant reversal effect on TRAIL resistance in human gastric adenocarcinoma (AGS) cells. (C) 2009 Elsevier Ltd. All rights reserved.
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