Journal
TETRAHEDRON LETTERS
Volume 50, Issue 21, Pages 2512-2515Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.03.065
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Funding
- National Museum of Marine Biology Aquarium
- National Science Council of Taiwan [NSC97-2113-M-291-001]
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Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyo-toxicity with LD50 value of 0.28 mu M, and antifungal activity against Aspergillus niger. (C) 2009 Elsevier Ltd. All rights reserved.
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