4.4 Article

Synthesis of novel spiropyrrolidine/pyrrolizine-oxindole scaffolds through 1,3-dipolar cycloadditions

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 33, Pages 4724-4726

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.06.033

Keywords

Sarcosine; Azomethine ylide; Spirooxindole; Cycloaddition

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The one-pot, three-component condensation of sarcosine or proline Schiff bases with several aromatic alclehydes and the Knoevenagel adduct of isatin-malononitrile successfully affords spiropyrrolidine-oxindoles and spiropyrrolizine-oxindoles. (C) 2009 Elsevier Ltd. All rights reserved.

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